This paper studies the distribution network design problem considering the uncertain information in the demand, capacities, costs and prices in a multi-product environment and multiple periods. We consider a fractional objective function that consist in maximize the ratio between total profit and total cost. We use a model that integrates a facility location problem with a distribution network problem with fuzzy constraints, technological coefficients, and costs. To solve the problem, we use a method that transform the fuzzy linear fractional programming model in an equivalent multi-objective linear fractional programming problem to calculate the upper, middle and lower bounds of the original problem.