Given that the Covid-19 pandemic resulted in an unprecedented scenario, there were no previous lessons learned about the organizational responses to social problems. As a result of the above this chapter describes the practices used by seven Colombian organizations to face the first months of the pandemic, based on Corporate Social Innovation framework. A qualitative approach was used to carry out the study and a qualitative content analysis as a research method. The results obtained indicate that the companies participating in our research, developed actions in the four pillars, with actions associated with social issues being more prevalent, especially concerning workers and vulnerable populations.