Heterotopía nodular periventricular, objetivo quirúrgico en epilepsia refractaria al manejo farmacológico
Artículo académico
Visión General
Visión General
Abstracto
Introduction: Neuronal heterotopia is a migration disorder in which these cells do not complete their movement toward the cerebral cortex. Periventricular nodular heterotopia is the most frequently reported form, characterized by neuronal conglomerates adjacent to the lateral ventricles walls. About 90 % of patients with this condition suffer epilepsy at some point in their life and the major proportion of them will be resistant to pharmacologic treatment. This makes necessary an appropriate diagnostic approach to determine which patients would benefit from surgical resection of the lesion, which in most cases offers a high rate of crisis control. Development: This article presents a review of the most important topics from practice about periventricular nodular heterotopia pathophysiology, clinical features, diagnostic and therapeutic approach. Its aim is to explore the role of this condition as a cause of intractable epilepsy. Conclusion: Pharmacologic treatment resistant epilepsy will have a severe impact on patient’s quality of life. Periventricular nodular heterotopia is frequently associated to this condition, which must be successfully approached by the medical team attempting to opportune diagnosis and defining which patients benefit from surgical management. This positively impacts the quality of life of these patients and their caregivers.
