AbstractAIDS-related mycoses remain important causes of morbidity (oropharyngeal and esophageal candidiasis) and mortality (cryptococcosis, histoplasmosis, pneumocystosis, emergomycosis and talaromycosis) in persons living with HIV globally and within endemic areas. Overlapping epidemiological and clinical features make diagnosis challenging, particularly in high tuberculosis-burden regions. Recent advances in diagnostics and management have improved outcomes, but substantial challenges remain. This article provides an overview of important HIV-associated invasive mycoses, covering epidemiology, clinical presentation, diagnosis, and management, including considerations around antiretroviral therapyKeywordsAIDSCryptococcal meningitisCryptococcosisEmergomycosisEsophageal candidiasisHistoplasmosisHIVOropharyngeal candidiasisPneumocystis pneumoniaPneumocystosisProgressive disseminated histoplasmosisTalaromycosis